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In this work it's vitally important that we not be reductionist in our approach. We are more than our neurons (brains) and until we start taking this "more than" seriously, we are participating in the same unhelpful reductionism that got us into the mess we're in now. Here's an article that brings together a few different perspectives (neurobiology, psychology, spirituality) to paint a more complete understanding of how and why these substances help us in our deep healing. What you'll read is that uncomfortable, challenging, and even scary experiences are a necessary part of the healing process...not something to be avoided by the development of "safer medicines."